Making a diagnosis of mesothelioma is often difficult, because the symptoms seen with this disease are similar to those of many other medical conditions. In order to make a diagnosis, a doctor will review the patient's medical history, conduct a physical exam, and recommend specific tests and procedures to confirm the diagnosis. Some of these tests and procedures may include CT scans, biopsy, and surgery.

Mesothelioma Diagnosis: An Overview
Making a mesothelioma diagnosis is often difficult because mesothelioma symptoms are similar to those of a number of other conditions.

In order to make a diagnosis of mesothelioma, the healthcare provider will begin with a review of the patient's medical history, including any history of asbestos exposure. He or she will then perform a complete physical examination to look for signs or symptoms of mesothelioma. The doctor may also order some preliminary tests to rule out other, more common conditions. These tests can include x-rays of the chest or abdomen and lung function tests.

Tests and Procedures
If the doctor suspects mesothelioma after the history and physical exam, he or she may order a number of tests to help make a diagnosis.

Some of these tests include:

* CT Scan
* MRI
* Biopsy
* Thoracoscopy
* Peritoneoscopy
* Surgery.

CT Scan/MRI
A CT (or CAT) scan or an MRI may also be useful in making a diagnosis. A CT scan is a series of detailed pictures of areas inside the body created by a computer linked to an x-ray machine. In an MRI, a powerful magnet linked to a computer is used to make detailed pictures of areas inside the body. These pictures are viewed on a monitor and can also be printed.

Biopsy
A biopsy is needed to confirm a mesothelioma diagnosis. In a biopsy, a surgeon or a medical oncologist (a doctor who specializes in diagnosing and treating cancer) removes a sample of tissue for examination under a microscope by a pathologist. A biopsy may be performed in different ways, depending on where the abnormal area is located.

Thoracoscopy
If the cancer is in the chest, the doctor may perform a thoracoscopy. In this procedure, the doctor makes a small cut through the chest wall and puts a thin, lighted tube called a thoracoscope into the chest between two ribs. Thoracoscopy allows the doctor to look inside the chest and obtain tissue samples.

Peritoneoscopy
If the cancer is in the abdomen, the doctor may perform a peritoneoscopy. To obtain tissue for examination, the doctor makes a small opening in the abdomen and inserts a special instrument called a peritoneoscope into the abdominal cavity.

Surgery
If these procedures do not yield enough tissue to make a diagnosis, more extensive diagnostic surgery may be necessary.

Mesothelioma Diagnosis and Staging
If the doctor makes a diagnosis of mesothelioma, he or she will want to determine the mesothelioma stage.

Staging involves more tests in a careful attempt to learn whether the cancer has spread and, if so, to which parts of the body. Knowing the stage of the disease helps the doctor plan mesothelioma treatment.

Mesothelioma is described as localized if the cancer is found only on the membrane surface where it originated. It is classified as advanced if it has spread beyond the original membrane surface to other parts of the body, such as the lymph nodes, lungs, chest wall, or abdominal organs.